发明公开
EP2982668A3 2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS
审中-公开
2-（2-羟基联苯-3-基）-1H-苯并咪唑-5-甲脒衍生物作为凝血因子Ⅶa抑制剂用于治疗血栓栓塞性病症的
- 专利标题： 2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS
- 专利标题（中）： 2-（2-羟基联苯-3-基）-1H-苯并咪唑-5-甲脒衍生物作为凝血因子Ⅶa抑制剂用于治疗血栓栓塞性病症的
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申请号： EP15164898.7申请日： 2003-12-03
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公开(公告)号： EP2982668A3公开(公告)日： 2016-04-13
- 发明人: KOLESNIKOV, Aleksandr , RAI, Roopa , SHRADER, William, Dvorak , TORKELSON, Steven, M. , WESSON, Kieron, E. , YOUNG, Wendy, B.
- 申请人： Pharmacyclics LLC
- 申请人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 专利权人： Pharmacyclics LLC
- 当前专利权人： Pharmacyclics LLC
- 当前专利权人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 代理机构： Walker, Ross Thomson
- 优先权： US430981P 20021203
- 主分类号： C07D235/18
- IPC分类号： C07D235/18 ; C07D401/12 ; C07D403/10 ; C07D407/12 ; C07D471/04
摘要：
The present invention relates to 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors for the treatment of thromboembolic disorders, cancers and rheumatoid arthritis. Processes for preparing these inhibitors and intermediates thereof are also disclosed.
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