发明公开
- 专利标题： WT1-ANTIGEN PEPTIDE CONJUGATE VACCINE
- 专利标题（中）： WT1-抗原肽共轭疫苗
-
申请号： EP14775899.9申请日： 2014-03-28
-
公开(公告)号： EP2982681A1公开(公告)日： 2016-02-10
- 发明人: LI, Chiang Jia , BAN, Hitoshi , NISHIO, Yukihiro , GOTO, Masashi , NISHIHARA, Toshio , TAKANASHI, Yosuke
- 申请人： Sumitomo Dainippon Pharma Co., Ltd. , International Institute of Cancer Immunology, Inc.
- 申请人地址： 6-8, Dosho-machi 2-chome Chuo-ku Osaka-shi Osaka 541-8524 JP
- 专利权人： Sumitomo Dainippon Pharma Co., Ltd.,International Institute of Cancer Immunology, Inc.
- 当前专利权人： Sumitomo Dainippon Pharma Co., Ltd.,International Institute of Cancer Immunology, Inc.
- 当前专利权人地址： 6-8, Dosho-machi 2-chome Chuo-ku Osaka-shi Osaka 541-8524 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2013072173 20130329; JP2013158383 20130731
- 国际公布： WO2014157692 20141002
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61K39/00 ; A61P35/00 ; C07K7/08 ; C07K14/00
摘要：
The present invention provides a compound represented by the formula (1):
wherein X a and Y a are each a single bond and the like,
cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, R 1 is a hydrogen atom, a group represented by the formula (2):
wherein X b and Y b are each a single bond and the like,
cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, or cancer antigen peptide C, and
cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7 - 30 amino acid residues containing one cysteine residue,
or a salt thereof, and the like.
wherein X a and Y a are each a single bond and the like,
cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, R 1 is a hydrogen atom, a group represented by the formula (2):
wherein X b and Y b are each a single bond and the like,
cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, or cancer antigen peptide C, and
cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7 - 30 amino acid residues containing one cysteine residue,
or a salt thereof, and the like.
公开/授权文献
- EP2982681B1 WT1-ANTIGEN PEPTIDE CONJUGATE VACCINE 公开/授权日：2018-08-22
信息查询
