发明公开
EP2991983A1 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES 有权
2-苯基-2-甲基咪唑并[1,2-A]吡啶衍生物

2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
摘要:
The invention relates to compounds of formulas I and II, formula I or formula II wherein R
1 is hydrogen, lower alkyl, lower alkoxy, halogen, S-lower alkyl, lower alkoxy substituted by halogen, di-lower alkyl amino, C(O)O-lower alkyl, lower alkyl substituted by hydroxy or hydroxy; R
2 is hydrogen, lower alkyl, halogen, lower alkoxy, S-lower alkyl, lower alkoxy substituted by halogen, O(CH
2 )
2 -lower alkoxy substituted by halogen, di-lower alkyl amino, alkyl amino, NH-lower alkyl substituted by halogen, N(lower alkyl)-benzyl, lower alkyl substituted by hydroxy, heterocycloalkyl optionally substituted by halogen, CH
2 -lower alkoxy, CH
2 -lower alkoxy substituted by halogen or hydroxy; or R
1 and R
2 form together with the carbon atoms to which they are attached a ring containing -OCH
2 CH
2 O-, OCH
2 O-, OCH
2 CH
2 CH
2 O- or -NHC(O)CH
2 O-; R
3 is hydrogen or lower alkoxy; R
4 is hydrogen or lower alkyl; R
5 is lower alkyl, cycloalkyl, lower alkyl substituted by hydroxy or lower alkyl substituted by halogen; or R
4 and R
5 form together with the nitrogen atom to which they are attached a ring containing -CH
2 CH
2 CHRCH
2 CH
2 -, -CH
2 CHRCH
2 CH
2 -, -CH
2 CH
2 OCH
2 CH
2 -, -CH
2 CH
2 NR'CH
2 CH
2 -, CH
2 CHR- or -CH
2 CH
2 CH
2 -; wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen; R' is lower alkyl substituted by halogen; R
a is hydrogen or H; R
b is hydrogen, hydroxy or
3 H; R
6 is hydrogen, halogen or lower alkyl; HetAr is selected from the group consisting of thiophenyl, furanyl, thiozolyl, benzofuranyl, pyrazolyl, benzoimidazolyl or pyridinyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The present compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer's disease.
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