发明公开
EP2993170A1 N-[4-(2-OXO-1,2-DIHYDRO-PYRIDIN-4-YL)-BENZYL]-BENZAMIDE DERIVATIVES AS ALDH-2 INHIBITORS FOR THE TREATMENT OF ADDICTION
有权
N- [4-（2-氧代-1,2-二氢 - 吡啶-4-基） - 苯基] - 苯甲酸衍生物ALS ALDH-2抑制剂ZUR SUCHTBEHANDLUNG
- 专利标题： N-[4-(2-OXO-1,2-DIHYDRO-PYRIDIN-4-YL)-BENZYL]-BENZAMIDE DERIVATIVES AS ALDH-2 INHIBITORS FOR THE TREATMENT OF ADDICTION
- 专利标题（中）： N- [4-（2-氧代-1,2-二氢 - 吡啶-4-基） - 苯基] - 苯甲酸衍生物ALS ALDH-2抑制剂ZUR SUCHTBEHANDLUNG
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申请号： EP15184883.5申请日： 2012-06-29
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公开(公告)号： EP2993170A1公开(公告)日： 2016-03-09
- 发明人: CANNIZZARO, Carina, E. , GRAUPE, Michael , GUERRERO, Juan, A. , LU, Yafan , STICKLEY, Robert, G. , VENKATARAMANI, Chandrasekar , ZABLOCKI, Jeff
- 申请人： Gilead Sciences, Inc.
- 申请人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 代理机构： Lumsden, Stuart Edward Henry
- 优先权： US201161503923P 20110701
- 主分类号： C07D213/64
- IPC分类号： C07D213/64 ; A61K31/4418 ; A61P25/30 ; A61P25/32 ; A61P25/34 ; A61P25/36
摘要：
Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction.
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