发明公开
- 专利标题： REVERSIBLE HEPARIN MOLECULES
- 专利标题（中）： UMKEHRBAREHEPARINMOLEKÜLE
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申请号： EP14812890.3申请日： 2014-06-17
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公开(公告)号： EP3011043A2公开(公告)日： 2016-04-27
- 发明人: LIU, Jian , XU, Yongmei , LINHARDT, Robert, J. , HARRIS, Edward
- 申请人： The University of North Carolina at Chapel Hill , Rensselaer Polytechnic Institute , The Board of Regents of the University of Nebraska
- 申请人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 专利权人： The University of North Carolina at Chapel Hill,Rensselaer Polytechnic Institute,The Board of Regents of the University of Nebraska
- 当前专利权人： The University of North Carolina at Chapel Hill,Rensselaer Polytechnic Institute,The Board of Regents of the University of Nebraska
- 当前专利权人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 代理机构： Isarpatent
- 优先权： US201361835875P 20130617
- 国际公布： WO2014204929 20141224
- 主分类号： C12P19/18
- IPC分类号： C12P19/18 ; C08B37/10
摘要：
Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
公开/授权文献
- EP3011043B1 REVERSIBLE HEPARIN MOLECULES 公开/授权日：2022-05-11
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