发明公开
EP3011332A1 NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS
有权
特发性脊柱侧凸的艰难历程和新的标记及其用途为脊柱侧凸患者舱与预测发生脊柱侧弯的风险
- 专利标题： NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS
- 专利标题（中）： 特发性脊柱侧凸的艰难历程和新的标记及其用途为脊柱侧凸患者舱与预测发生脊柱侧弯的风险
-
申请号： EP14814488.4申请日： 2014-06-17
-
公开(公告)号： EP3011332A1公开(公告)日： 2016-04-27
- 发明人: MOREAU, Alain , AKOUME NDONG, Marie-Yvonne , ELBAKRY, Mohamed
- 申请人： CHU Sainte-Justine
- 申请人地址： 3175 Côte Ste-Catherine Montréal, Québec H3T 1C5 CA
- 专利权人： CHU Sainte-Justine
- 当前专利权人： CHU Sainte-Justine
- 当前专利权人地址： 3175 Côte Ste-Catherine Montréal, Québec H3T 1C5 CA
- 代理机构： Marro, Nicolas
- 优先权： US201361835698P 20130617
- 国际公布： WO2014201560 20141224
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; A61K31/135 ; A61K31/519 ; A61K31/713
摘要：
Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.
信息查询
