A machine tool (1) of high-frequency vibration is provided. A main shaft structure (100) of the machine tool (1) comprises a rotating shaft (120), the end of which is provided with a tool holder chuck (130) for fixing a tool holder (200); the upper portion of which is provided with a rotating coil portion (150); the main shaft structure (100) is correspondingly provided with a stationary coil portion (140); and the tool holder (200) is provided with a high-frequency vibration module (240). By non-contact coils (140, 150), an external electric power/signal can be transmitted into the high-frequency vibration module (240) to avoid a wear phenomenon in a contact-rotating electrode. Because the inductive coil (140, 150) is arranged outside of the tool holder (200), the manufacturing cost of the tool holder (200) is reduced, and the convenience of changing the tool holder (200) is increased. Moreover, the machining stability and efficiency of the tool holder (200) are improved by a control method of sensing/feedback signals with wireless transmission.