发明公开
EP3018122A1 4-(P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES
审中-公开
4-（对 - 喹啉）-2-羟基丁酰胺衍生物UR UNG UNG ON ON EN EN EN EN EN EN EN EN EN EN
- 专利标题： 4-(P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES
- 专利标题（中）： 4-（对 - 喹啉）-2-羟基丁酰胺衍生物UR UNG UNG ON ON EN EN EN EN EN EN EN EN EN EN
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申请号： EP15190273.1申请日： 2008-11-04
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公开(公告)号： EP3018122A1公开(公告)日： 2016-05-11
- 发明人: JANKOWSKI, Orion, D. , WESSON, Kieron, E. , MOLLARD, Paul , SHRADER, William, D
- 申请人： Edison Pharmaceuticals, Inc.
- 申请人地址： 350 North Bernardo Avenue Mountain View, CA 94043 US
- 专利权人： Edison Pharmaceuticals, Inc.
- 当前专利权人： Edison Pharmaceuticals, Inc.
- 当前专利权人地址： 350 North Bernardo Avenue Mountain View, CA 94043 US
- 代理机构： Sexton, Jane Helen
- 优先权： US2126 20071106; US2127 20071106
- 主分类号： C07C235/78
- IPC分类号： C07C235/78 ; C07C317/28 ; C07D213/40 ; C07D223/04 ; C07D233/61 ; C07D295/02 ; C07D307/14 ; C07D295/192 ; C07D295/185 ; C07D207/27 ; C07D295/24 ; A61K31/16 ; A61K31/445 ; A61P25/16 ; A61P25/00 ; A61P27/00 ; A61P21/00
摘要：
The present invention provides specific 4-(p-quinonyl)-2-hydroxybutanamide derivative compounds, pharmaceutical compositions comprising them, and those compounds and compositions for use methods of treating or suppressing a mitochondrial disorder, modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, and treating a subject suffering from a pervasive developmental disorder selected from the group consisting of Autistic Disorder, Asperger's Disorder, Childhood Disintegrative Disorder (CDD), Rett's Disorder, and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS).
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