发明公开
EP3019532A1 CERTAIN IMPROVED HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES
审中-公开
BESTIMMTE MENSCHLICHE BISPEZIFISCHE EGFRVI-ANTIKÖRPER-BINDENDEMOLEKÜLE
- 专利标题： CERTAIN IMPROVED HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES
- 专利标题（中）： BESTIMMTE MENSCHLICHE BISPEZIFISCHE EGFRVI-ANTIKÖRPER-BINDENDEMOLEKÜLE
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申请号： EP14823231.7申请日： 2014-07-09
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公开(公告)号： EP3019532A1公开(公告)日： 2016-05-18
- 发明人: BIGNER, Darell D. , SAMPSON, John , KUAN, Chien-Tsun , CAI, Mingqing , CHOI, Bryan D. , GEDEON, Patrick C. , PASTAN, Ira H.
- 申请人： Duke University , The Government of the United States, as represented by The Secretary of the Department of Health and Human Services
- 申请人地址： 2812 Erwin Road, Suite 306 P.O. Box 90083 Durham, North Carolina 27705 US
- 专利权人： Duke University,The Government of the United States, as represented by The Secretary of the Department of Health and Human Services
- 当前专利权人： Duke University,The Government of the United States, as represented by The Secretary of the Department of Health and Human Services
- 当前专利权人地址： 2812 Erwin Road, Suite 306 P.O. Box 90083 Durham, North Carolina 27705 US
- 代理机构： Tombling, Adrian George
- 优先权： US201361844119P 20130709
- 国际公布： WO2015006482 20150115
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C12N15/13 ; A61P35/00 ; A61K39/395
摘要：
We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are therapeutic agents.
公开/授权文献
- EP3019532B1 HUMAN BISPECIFIC EGFRVIII ANTIBODY ENGAGING MOLECULES 公开/授权日：2019-01-02
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