发明公开
- 专利标题： CYANOTRIAZOLE COMPOUNDS
- 专利标题（中）： 氰基三唑化合物
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申请号： EP14748306.9申请日： 2014-07-16
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公开(公告)号： EP3022199A1公开(公告)日： 2016-05-25
- 发明人: SATO, Seiji , MATSUDA, Satoshi , MATSUMURA, Chiharu , ITOTANI, Motohiro , SHINOHARA, Toshio , FUJITA, Shigekazu , SAKURAI, Yohji , TAI, Kuninori , FUKUSHIMA, Tae , KANEMOTO, Naohide , OKAMOTO, Takashi
- 申请人： Otsuka Pharmaceutical Co., Ltd.
- 申请人地址： 2-9, Kanda Tsukasamachi Chiyoda-ku Tokyo 101-8535 JP
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： 2-9, Kanda Tsukasamachi Chiyoda-ku Tokyo 101-8535 JP
- 代理机构： von Kreisler Selting Werner - Partnerschaft von Patentanwälten und Rechtsanwälten mbB
- 优先权： US201361847268P 20130717; US201361885254P 20131001; US201461928267P 20140116
- 国际公布： WO2015008872 20150122
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/12 ; C07D403/14 ; C07D405/12 ; C07D411/12 ; C07D411/14 ; C07D413/12 ; C07D417/12 ; C07D417/14 ; C07D249/04 ; C07D249/06 ; A61K31/4192
摘要：
This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.
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