发明公开
EP3022305A2 FUSOKINES INVOLVING CYTOKINES WITH STRONGLY REDUCED RECEPTOR BINDING AFFINITIES
有权
FUSOKINE，ZYTOKINE ENTHALTEND，MIT MASSIV REDUZIERTER REZEPTOR-BINDUNGSAFFINITÄT。
- 专利标题： FUSOKINES INVOLVING CYTOKINES WITH STRONGLY REDUCED RECEPTOR BINDING AFFINITIES
- 专利标题（中）： FUSOKINE，ZYTOKINE ENTHALTEND，MIT MASSIV REDUZIERTER REZEPTOR-BINDUNGSAFFINITÄT。
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申请号： EP14734831.2申请日： 2014-07-03
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公开(公告)号： EP3022305A2公开(公告)日： 2016-05-25
- 发明人: TAVERNIER, Jan , BULTINCK, Jennyfer , GERLO, Sarah , UZÉ, Gilles , PAUL, Franciane , BORDAT, Yann
- 申请人： VIB VZW , Universiteit Gent , Centre National de la Recherche Scientifique , Université Montpellier 2 , Centre Hospitalier Regional Universitaire De Montpellier
- 申请人地址： Rijvisschestraat 120 9052 Gent BE
- 专利权人： VIB VZW,Universiteit Gent,Centre National de la Recherche Scientifique,Université Montpellier 2,Centre Hospitalier Regional Universitaire De Montpellier
- 当前专利权人： VIB VZW,Universiteit Gent,Centre National de la Recherche Scientifique,Université Montpellier 2,Centre Hospitalier Regional Universitaire De Montpellier
- 当前专利权人地址： Rijvisschestraat 120 9052 Gent BE
- 代理机构： Grund, Martin
- 优先权： EP13306034 20130718
- 国际公布： WO2015007536 20150122
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; A61K38/19 ; A61K38/21 ; A61K38/20 ; C07K14/56 ; C07K14/52 ; C07K14/545 ; C07K14/525 ; C07K14/575
摘要：
The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced binding affinity to its receptor, or to one of its receptors. Preferably, both cytokines are connected by a linker, preferably a GGS linker. The invention relates further to said fusion protein for use in treatment of diseases.
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