发明公开
- 专利标题： QUINOLINE DERIVATIVE
- 专利标题（中）： CHINOLINDERIVAT
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申请号： EP14828976.2申请日： 2014-07-23
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公开(公告)号： EP3026045A1公开(公告)日： 2016-06-01
- 发明人: INUKAI, Takayuki , TAKEUCHI, Jun , YASUHIRO, Tomoko
- 申请人： ONO Pharmaceutical Co., Ltd.
- 申请人地址： 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 专利权人： ONO Pharmaceutical Co., Ltd.
- 当前专利权人： ONO Pharmaceutical Co., Ltd.
- 当前专利权人地址： 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 代理机构： Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权： JP2013153350 20130724
- 国际公布： WO2015012298 20150129
- 主分类号： C07D215/54
- IPC分类号： C07D215/54 ; A61K31/4709 ; A61K31/5377 ; A61P9/00 ; A61P13/12 ; A61P25/02 ; A61P35/00 ; A61P35/04 ; A61P37/02 ; A61P43/00 ; C07D401/14
摘要：
A compound represented by general formula (I):
has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.
has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.
公开/授权文献
- EP3026045B1 QUINOLINE DERIVATIVE 公开/授权日：2018-10-03
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