发明公开
- 专利标题： METHOD FOR PREDICTING PATIENT'S RESPONSE TO BIGLYCAN TREATMENT
- 专利标题（中）： 预测患者对大规模治疗反应的方法
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申请号： EP15188122.4申请日： 2011-12-27
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公开(公告)号： EP3026432A2公开(公告)日： 2016-06-01
- 发明人: AMENTA, Alison R. , YILMAZ, Atilgan , McKECHNIE, Beth A. , FALLON, Justin R.
- 申请人： Brown University
- 申请人地址： 1 Prospect Street, Box 1949 Providence, RI 02912-1949 US
- 专利权人： Brown University
- 当前专利权人： Brown University
- 当前专利权人地址： 1 Prospect Street, Box 1949 Providence, RI 02912-1949 US
- 代理机构： Gibbs, Richard
- 优先权： US201061427468P 20101227
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/68
摘要：
The present discloure provides methods for predicting a patient's response to biglycan therapy for diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of such diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. This application also provides combination therapeutics, such as a biglycan therapeutic and a utrophin therapeutic.
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