发明公开
EP3027612A1 11-OXO-10,11-DIHYDRODIBENZO[B,F][1,4]THIAZEPINE S-OXIDE DERIVATIVES AND THEIR USE AS DOPAMINE D2 RECEPTOR ANTAGONISTS
审中-公开
11-OXO-10,11-二氢苯并咪唑[B,F] [1,4]噻吩并-S-氧化物在DEREN VERWENDUNG ALS DOPAMIN-D2-REZEPTORANTAGONISTEN
- 专利标题: 11-OXO-10,11-DIHYDRODIBENZO[B,F][1,4]THIAZEPINE S-OXIDE DERIVATIVES AND THEIR USE AS DOPAMINE D2 RECEPTOR ANTAGONISTS
- 专利标题(中): 11-OXO-10,11-二氢苯并咪唑[B,F] [1,4]噻吩并-S-氧化物在DEREN VERWENDUNG ALS DOPAMIN-D2-REZEPTORANTAGONISTEN
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申请号: EP14750663.8申请日: 2014-07-29
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公开(公告)号: EP3027612A1公开(公告)日: 2016-06-08
- 发明人: MARUGAN, Juan Jose , XIAO, Jingbo , FERRER, Marc , SOUTHALL, Noel Terrence , FREE, R. Benjamin , SIBLEY, David Robert
- 申请人: The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 申请人地址: Office of Technology Transfer National Institues of Health 6001 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 专利权人: The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人: The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址: Office of Technology Transfer National Institues of Health 6001 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 代理机构: Harris, Oliver John Richard
- 优先权: US201361859532P 20130729
- 国际公布: WO2015017412 20150205
- 主分类号: C07D417/12
- IPC分类号: C07D417/12 ; C07D281/16 ; A61K31/554 ; A61P25/14 ; A61P25/18 ; A61P25/24
摘要:
The disclosure includes compounds and pharmaceutically acceptable salts of Formula (I). Certain compounds and salts of Formula (I) are selective inhibitors of the Dopamine D2 receptor. The variables R1-R4, n, and L are defined herein. The disclosure also provides methods of synthesizing compounds of Formula (I) and pharmaceutical compositions containing compounds of Formula (I). Additionally the disclosure provides methods or treating patients suffering from central nervous system disorders, including Tourette's syndrome, bipolar disorder, hyperprolactinemia, tardive dyskinesia, Huntington's chorea, psychosis, depression, or schizophrenia.
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