发明公开
- 专利标题： RECOMBINANT VECTOR WITH OPTIMIZED A-BULGE
- 专利标题（中）： 具有改进的A-VAULT重组载体
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申请号： EP14835030.9申请日： 2014-08-05
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公开(公告)号： EP3030659A1公开(公告)日： 2016-06-15
- 发明人: LIN, Amy H. , GRUBER, Harry E. , IBANEZ, Carlos , JOLLY, Douglas J.
- 申请人： Tocagen Inc.
- 申请人地址： 3030 Bunker Hill Street Suite 230 San Diego, CA 92109 US
- 专利权人： Tocagen Inc.
- 当前专利权人： Tocagen Inc.
- 当前专利权人地址： 3030 Bunker Hill Street Suite 230 San Diego, CA 92109 US
- 代理机构： Gill Jennings & Every LLP
- 优先权： US201361862433P 20130805
- 国际公布： WO2015021077 20150212
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
The disclosure describes replication competent retroviral vectors (RCR) for gene therapy and gene delivery. The RCR includes an IRES sequence having 6-7 A's in A-bulge of the bifurcation region. The disclosure provides recombinant replication competent retrovirus comprising: a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a retroviral polynucleotide comprising Long-Terminal Repeat (LTR) sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide.
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