发明公开
EP3033097A2 FACTOR VIII-XTEN FUSIONS AND USES THEREOF
审中-公开
FAKTOR-VIII-X-TEN-FUSIONEN SOWIE VERWENDUNGEN DAVON
- 专利标题： FACTOR VIII-XTEN FUSIONS AND USES THEREOF
- 专利标题（中）： FAKTOR-VIII-X-TEN-FUSIONEN SOWIE VERWENDUNGEN DAVON
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申请号： EP14835828.6申请日： 2014-08-14
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公开(公告)号： EP3033097A2公开(公告)日： 2016-06-22
- 发明人: LIU, Tongyao , CHANG, Pei-Yun , KULMAN, John , SCHELLENBERGER, Volker , JIANG, Haiyan , PETERS, Robert, T. , CHHABRA, Ekta, Seth
- 申请人： Biogen MA Inc. , Amunix Operating Inc.
- 申请人地址： 250 Binney Street Cambridge, MA 02142 US
- 专利权人： Biogen MA Inc.,Amunix Operating Inc.
- 当前专利权人： Biogen MA Inc.,Amunix Operating Inc.
- 当前专利权人地址： 250 Binney Street Cambridge, MA 02142 US
- 代理机构： Miller, David James
- 优先权： US201361866016P 20130814
- 国际公布： WO2015023891 20150219
- 主分类号： A61K38/36
- IPC分类号： A61K38/36 ; A61K38/37 ; A61K35/14 ; C07K1/00 ; C07K14/745 ; C07K14/755
摘要：
The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.
公开/授权文献
- EP3033097B1 FACTOR VIII-XTEN FUSIONS AND USES THEREOF 公开/授权日：2021-03-10
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