发明公开
EP3035950A1 GLYCOSYLATED PACAP/VIP ANALOGUES WITH ENHANCED CNS PENETRATION FOR TREATMENT OF NEURODEGENERATIVE DISEASES
审中-公开
GLYKOSYLIERTE PACAP / VIP-ANALOGA MIT VERBESSERTER PENETRATION ZUR BEHANDLUNG NEURODEGENERATIVER ERKRANKUNGEN
- 专利标题： GLYCOSYLATED PACAP/VIP ANALOGUES WITH ENHANCED CNS PENETRATION FOR TREATMENT OF NEURODEGENERATIVE DISEASES
- 专利标题（中）： GLYKOSYLIERTE PACAP / VIP-ANALOGA MIT VERBESSERTER PENETRATION ZUR BEHANDLUNG NEURODEGENERATIVER ERKRANKUNGEN
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申请号： EP14835775.9申请日： 2014-08-14
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公开(公告)号： EP3035950A1公开(公告)日： 2016-06-29
- 发明人: POLT, Robin , FALK, Torsten, A E
- 申请人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
- 申请人地址： University of Arizona Tech Transfer Arizona University Services Annex, 4th Floor PO Box 210300A Tucson, AZ 85721-0300 US
- 专利权人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
- 当前专利权人： The Arizona Board Of Regents On Behalf Of The University Of Arizona
- 当前专利权人地址： University of Arizona Tech Transfer Arizona University Services Annex, 4th Floor PO Box 210300A Tucson, AZ 85721-0300 US
- 代理机构： Prinz & Partner mbB
- 优先权： US201361865958P 20130814
- 国际公布： WO2015023890 20150219
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P25/02 ; A61K38/00
摘要：
A glycosylated pleiotropic peptide pituitary adenylate cyclase-activating polypeptide (PACAP) which can both agonize PAC1 receptors, causing neuroprotective effects, and antagonize VPAC receptors, causing anti-inflammation in several models of acute neuronal damage and neurodegenerative diseases, including ALS, PD, migraines, and certain forms of dementia, is described. Also described is a method of relieving symptoms of ALS, PD, migraines, and certain forms of dementia, comprising administering to a subject in need thereof an effective amount of a glycosylated PACAP.
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