发明公开
EP3036238A1 FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
审中-公开
FURO-UND THIENO-吡啶羧酰胺 - 维生素D
- 专利标题： FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
- 专利标题（中）： FURO-UND THIENO-吡啶羧酰胺 - 维生素D
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申请号： EP14766267.0申请日： 2014-08-22
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公开(公告)号： EP3036238A1公开(公告)日： 2016-06-29
- 发明人: LI, Yun-Long , BURNS, David M. , FENG, Hao , HUANG, Taisheng , MEI, Song , PAN, Jun , VECHORKIN, Oleg , YE, Hai Fen , ZHU, Wenyu , RAFALSKI, Maria , WANG, Anlai , XUE, Chu-Biao
- 申请人： Incyte Corporation
- 申请人地址： Experimental Station Route 141&Henry Clay Road Building E336/207 Wilmington, Delaware 19880 US
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： Experimental Station Route 141&Henry Clay Road Building E336/207 Wilmington, Delaware 19880 US
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201361869442P 20130823
- 国际公布： WO2015027124 20150226
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; C07D495/04 ; A61K31/4355 ; A61K31/4365 ; A61K31/5025 ; A61P35/00 ; A61P37/02 ; A61P37/08 ; A61P9/10
摘要：
The present disclosure describes furo-and thieno-pyridine carboxamide compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is S or 0; A
5 is N or C-R
5 . Cy
A is a 5 to 6 membered monocyclic heteroaryl group, wherein the ring atoms of the heteroaryl group forming Cy
A consist of carbon atoms and 1, 2, or 3 heteroatoms selected from N, 0 and S, and wherein the 5 to 6 membered monocyclic heteroaryl group forming Cy
A is unsubstituted or substituted with 1, 2, or 3 R
A ; Cy
B is C
6-10 aryl, C
3-7 cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl wherein the ring atoms of the ring atoms of the heteroaryl or heterocycloalkyl forming Cy
B consist of carbon atoms and 1, 2 or 3 heteroatoms selected from 0, N and S, and wherein each of said C
6-10 aryl, C
3-7 cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl forming Cy
B is unsubstituted or substituted with 1, 2, 3, 4 or 5 R
B ; R
2 is H, halogen or NH
2 ; and R
5 , R
6 and R
7 are as defined in claim 1; The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
5 is N or C-R
5 . Cy
A is a 5 to 6 membered monocyclic heteroaryl group, wherein the ring atoms of the heteroaryl group forming Cy
A consist of carbon atoms and 1, 2, or 3 heteroatoms selected from N, 0 and S, and wherein the 5 to 6 membered monocyclic heteroaryl group forming Cy
A is unsubstituted or substituted with 1, 2, or 3 R
A ; Cy
B is C
6-10 aryl, C
3-7 cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl wherein the ring atoms of the ring atoms of the heteroaryl or heterocycloalkyl forming Cy
B consist of carbon atoms and 1, 2 or 3 heteroatoms selected from 0, N and S, and wherein each of said C
6-10 aryl, C
3-7 cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl forming Cy
B is unsubstituted or substituted with 1, 2, 3, 4 or 5 R
B ; R
2 is H, halogen or NH
2 ; and R
5 , R
6 and R
7 are as defined in claim 1; The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
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