发明授权
- 专利标题： DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
- 专利标题（中）： 双重机制抑制剂治疗疾病
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申请号： EP15002893.4申请日： 2010-01-27
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公开(公告)号： EP3053913B1公开(公告)日： 2018-03-07
- 发明人: DELONG, Mitchell A , STURDIVANT, Jill Marie , ROYALTY, Susan M.
- 申请人： AERIE PHARMACEUTICALS, INC.
- 申请人地址： 7020 Kit Creek Road, Suite 270, P.O. Box 12320 Research Triangle Park, NC 27709 US
- 专利权人： AERIE PHARMACEUTICALS, INC.
- 当前专利权人： AERIE PHARMACEUTICALS, INC.
- 当前专利权人地址： 7020 Kit Creek Road, Suite 270, P.O. Box 12320 Research Triangle Park, NC 27709 US
- 代理机构： Green, Mark Charles
- 优先权： US174672P 20090501
- 主分类号： C07D217/02
- IPC分类号： C07D217/02 ; C07D217/24 ; C07D401/12 ; C07D409/12 ; C07D417/12 ; C07C237/00 ; A61P27/00 ; A61K31/33 ; A61K31/47
摘要：
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
公开/授权文献
- EP3053913A1 DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE 公开/授权日：2016-08-10
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