Invention Publication
- Patent Title: FACTOR XIa INHIBITORS
- Patent Title (中): 因子XIa抑制剂
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Application No.: EP14851664.4Application Date: 2014-10-06
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Publication No.: EP3054944A1Publication Date: 2016-08-17
- Inventor: SHAO, Ning , EDMONDSON, Scott D. , NEELAMKAVIL, Santhosh , GUO, Zhuyan , MERTZ, Eric , ZANG, Yi , HE, Jiafang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Agency: Jaap, David Robert
- Priority: US201361887699P 20131007
- International Announcement: WO2015054087 20150416
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/7088 ; C07D413/14
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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