发明公开
EP3060056A2 USE OF STING AGONISTS TO TREAT CHRONIC HEPATITIS B VIRUS INFECTION
审中-公开
VERWENDUNG VON STING-AGONISTEN ZUR BEHANDLUNG VON CHRONISCHER HEPATITIS-B-VIRUSINFEKTION
- 专利标题： USE OF STING AGONISTS TO TREAT CHRONIC HEPATITIS B VIRUS INFECTION
- 专利标题（中）： VERWENDUNG VON STING-AGONISTEN ZUR BEHANDLUNG VON CHRONISCHER HEPATITIS-B-VIRUSINFEKTION
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申请号： EP14855900.8申请日： 2014-10-21
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公开(公告)号： EP3060056A2公开(公告)日： 2016-08-31
- 发明人: CHANG, Jinhong , GUO, Fang , BLOCK, Timothy M. , GUO, Ju-Tao
- 申请人： Drexel University
- 申请人地址： 3141 Chestnut Street Philadelphia, Pennsylvania 19104 US
- 专利权人： Drexel University
- 当前专利权人： Drexel University
- 当前专利权人地址： 3141 Chestnut Street Philadelphia, Pennsylvania 19104 US
- 代理机构： Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权： US201361893526P 20131021
- 国际公布： WO2015061294 20150430
- 主分类号： A01N43/76
- IPC分类号： A01N43/76 ; C07D263/30
摘要：
Provided herein are methods of treating a subject having hepatitis B viral (HBV) infection. More specifically, disclosed herein are methods of stimulating the innate cytokine response in macrophages, dendritic cells and/or liver non-parenchymal cells with small molecular agonists of STING to suppress HBV replication in hepatocytes. The methods are especially suitable for use in the treatment of chronic HBV infections. Also disclosed herein are methods of identifying compounds useful in the treatment of HBV infection.
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