发明公开
EP3060911A1 EXOSOME RECOVERY METHODS WITH LOW MOLECULAR WEIGHT ORGANIC ZWITTERIONS
审中-公开
EXOSOMGEWINNUNGSVERFAHREN MIT ORGANISCHEN ZWITTERIONEN VON NIEDRIGEM MOLEKULARGEWICHT
- 专利标题： EXOSOME RECOVERY METHODS WITH LOW MOLECULAR WEIGHT ORGANIC ZWITTERIONS
- 专利标题（中）： EXOSOMGEWINNUNGSVERFAHREN MIT ORGANISCHEN ZWITTERIONEN VON NIEDRIGEM MOLEKULARGEWICHT
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申请号： EP14855837.2申请日： 2014-10-15
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公开(公告)号： EP3060911A1公开(公告)日： 2016-08-31
- 发明人: GAGNON, Peter Stanley
- 申请人： Agency for Science, Technology and Research
- 申请人地址： 1 Fusionopolis Way 20-10 Connexis Singapore 138632 SG
- 专利权人： Agency for Science, Technology and Research
- 当前专利权人： Agency for Science, Technology and Research
- 当前专利权人地址： 1 Fusionopolis Way 20-10 Connexis Singapore 138632 SG
- 代理机构： Wilson, Gary
- 优先权： US201361895338P 20131024
- 国际公布： WO2015060784 20150430
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; A61K35/16 ; A61K35/22
摘要：
A method of isolating exosomes includes conducting at least one purification step in the presence of an organic zwitterion having a molecular weight of less than about 350 Daltons, a buffering pK of a negatively charged portion of the organic zwitterion is at least one full pH unit below an operating pH at which the at least one purification step is conducted, and a buffering pK of the positively charged portion of the organic zwitterion is at least one full pH unit above the operating pH.
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