发明公开
EP3063269A4 SUSPENSION AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS FOR DIFFERENTIATION INTO PANCREATIC ENDOCRINE CELLS
审中-公开
AUFHÄNGUNGUND GRUPPIERUNG MENSCHLICHER PLURIPOTENTER STAMMZELLEN ZUR DIFFERENZIERUNG IN ENDOKRINE PANKREASZELLEN
- 专利标题： SUSPENSION AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS FOR DIFFERENTIATION INTO PANCREATIC ENDOCRINE CELLS
- 专利标题（中）： AUFHÄNGUNGUND GRUPPIERUNG MENSCHLICHER PLURIPOTENTER STAMMZELLEN ZUR DIFFERENZIERUNG IN ENDOKRINE PANKREASZELLEN
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申请号： EP14859059申请日： 2014-06-17
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公开(公告)号： EP3063269A4公开(公告)日： 2017-07-12
- 发明人: FRYER BENJAMIN , LANIAUSKAS DAINA , BLACKMOORE MARCIA , WANG HAIYUN , LILOVA KOSTADINKA , NELSON SHELLEY , ROSOCHA ELIZABETH
- 申请人： JANSSEN BIOTECH INC
- 专利权人： JANSSEN BIOTECH INC
- 当前专利权人： JANSSEN BIOTECH INC
- 优先权： US201361962158 2013-11-01
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; A61K31/41 ; C07D403/00 ; C12N5/02 ; C12N5/0735 ; C12N5/077 ; C12N5/079
摘要：
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters.
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