发明公开
EP3074424A1 BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
审中-公开
GEGEN HER2 GERICHTETE BISPEZIFISCHE ANTIGENBINDENDE KONSTRUKTE
- 专利标题： BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
- 专利标题（中）： GEGEN HER2 GERICHTETE BISPEZIFISCHE ANTIGENBINDENDE KONSTRUKTE
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申请号： EP14866161.4申请日： 2014-11-27
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公开(公告)号： EP3074424A1公开(公告)日： 2016-10-05
- 发明人: WEISSER, Nina E. , NG, Gordon Yiu Kon , WICKMAN, Grant Raymond , DIXIT, Surjit Bhimarao , ESCOBAR-CABRERA, Eric , SANCHES, Mario
- 申请人： Zymeworks Inc.
- 申请人地址： 540-1385 West 8th Avenue Vancouver, British Colombia V6H 3V9 CA
- 专利权人： Zymeworks Inc.
- 当前专利权人： Zymeworks Inc.
- 当前专利权人地址： 540-1385 West 8th Avenue Vancouver, British Colombia V6H 3V9 CA
- 代理机构： Callaghan, Dayle Anne
- 优先权： US201361910026P 20131127; US201462000908P 20140520; US201462009125P 20140606
- 国际公布： WO2015077891 20150604
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; A61K39/395 ; A61K47/48 ; A61P35/00 ; C07K16/28 ; C12N15/13 ; C12N5/10 ; C40B40/08
摘要：
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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