发明公开
EP3074424A4 BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
审中-公开
GEGEN HER2 GERICHTETE BISPEZIFISCHE ANTIGENBINDENDE KONSTRUKTE
- 专利标题： BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
- 专利标题（中）： GEGEN HER2 GERICHTETE BISPEZIFISCHE ANTIGENBINDENDE KONSTRUKTE
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申请号： EP14866161申请日： 2014-11-27
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公开(公告)号： EP3074424A4公开(公告)日： 2017-06-14
- 发明人: WEISSER NINA E , NG GORDON YIU KON , WICKMAN GRANT RAYMOND , DIXIT SURJIT BHIMARAO , ESCOBAR-CABRERA ERIC , SANCHES MARIO
- 申请人： ZYMEWORKS INC
- 专利权人： ZYMEWORKS INC
- 当前专利权人： ZYMEWORKS INC
- 优先权： US201361910026 2013-11-27; US201462000908 2014-05-20; US201462009125 2014-06-06
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; A61K39/00 ; A61K39/395 ; A61K45/06 ; A61P35/00 ; C07K16/28 ; C07K16/30 ; C07K16/32 ; C12N5/10 ; C12N15/13 ; C40B40/08 ; G01N33/574
摘要：
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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