发明公开
- 专利标题: METHODS FOR THE ENRICHMENT OF MUTATED NUCLEIC ACID FROM A MIXTURE
- 专利标题(中): PROCESS富集突变核酸从混合物
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申请号: EP14805538.7申请日: 2014-11-25
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公开(公告)号: EP3074529A1公开(公告)日: 2016-10-05
- 发明人: SCHOENBRUNNER, Nancy , GUPTA, Amar , JANSSEN, Kevin
- 申请人: Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
- 申请人地址: Sandhofer Strasse 116 68305 Mannheim DE
- 专利权人: Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人: Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人地址: Sandhofer Strasse 116 68305 Mannheim DE
- 代理机构: Poredda, Andreas
- 优先权: US201361909587P 20131127
- 国际公布: WO2015078831 20150604
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68
摘要:
The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.
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