- 专利标题： PROCESS FOR THE PREPARATION OF (R)-3-(6-(4-METHYLPHENYL)-PYRIDIN-3-YLOXY)-1-AZA-BICYCLO[2.2.2]OCTANE BY REACTING 5-CHLORO-2-(4-METHYLPHENYL)PYRIDINE WITH (R)-3-HYDROXY-1-AZA-BICYCLO[2.2.2]OCTANE
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申请号： EP16162555.3申请日： 2012-07-12
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公开(公告)号： EP3075732B1公开(公告)日： 2018-09-12
- 发明人: MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Appleyard Lees IP LLP
- 优先权： US201161508147P 20110715
- 主分类号： C07D453/02
- IPC分类号： C07D453/02 ; A61K31/439 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/28
摘要：
The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.
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