发明公开
- 专利标题： WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS
- 专利标题（中）： WNT-WAY刺激重编程体细胞
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申请号： EP16171245.0申请日： 2008-08-29
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公开(公告)号： EP3078738A1公开(公告)日： 2016-10-12
- 发明人: CHEVALIER, Brett , MARSON, Alexander , YOUNG, Richard, A. , FOREMAN, Ruth , JAENISCH, Rudolf
- 申请人： Whitehead Institute for Biomedical Research
- 申请人地址： Five Cambridge Center Cambridge, MA 02142-1479 US
- 专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人： Whitehead Institute for Biomedical Research
- 当前专利权人地址： Five Cambridge Center Cambridge, MA 02142-1479 US
- 代理机构： Atkins, James Gordon John
- 优先权： US967028P 20070831; US188190P 20080806
- 主分类号： C12N5/02
- IPC分类号： C12N5/02 ; C12N5/074 ; A01N63/00 ; A61K48/00
摘要：
The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
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