发明公开
- 专利标题： THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
- 专利标题（中）： 甲硫氨酸硫酸酯酶
-
申请号： EP14872226.7申请日： 2014-12-18
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公开(公告)号： EP3083559A1公开(公告)日： 2016-10-26
- 发明人: ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , OTTE, Ryan D. , ELLIS, John Michael , BUTCHER, John W. , NORTHRUP, Alan B. , ROBICHAUD, Joel S. , GAUTHIER, Jacques Yves , FOURNIER, Jean-Francois
- 申请人： Merck Sharp & Dohme Corp. , Merck Canada Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： US201361918975P 20131220
- 国际公布： WO2015095445 20150625
- 主分类号： C07D213/72
- IPC分类号： C07D213/72
摘要：
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R
1 , R
2 , R
3 , R
4 , ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
1 , R
2 , R
3 , R
4 , ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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