- 专利标题： N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
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申请号： EP15703321.8申请日： 2015-01-16
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公开(公告)号： EP3094628B1公开(公告)日： 2018-08-08
- 发明人: CHEN, Christine Hiu-tung , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KARKI, Rajesh , KATO, Mitsunori , LAMARCHE, Matthew J. , PEREZ, Lawrence Blas , SMITH, Troy Douglas , WILLIAMS, Sarah , GIRALDES, John William , TOURE, Bakary-barry , SENDZIK, Martin
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Strang, Andrea Josephine
- 优先权： US201461928754P 20140117; US201461991129P 20140509
- 国际公布： WO2015107495 20150723
- 主分类号： C07D241/18
- IPC分类号： C07D241/18 ; C07D241/20 ; A61K31/495 ; A61P35/04
摘要：
in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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