发明公开
EP3095784A1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
审中-公开
APOPTOSEINDUKTOREN ZUR BEHANDLUNG冯KREBS SOWIE VON IMMUN- UND AUTOIMMUNERKRANKUNGEN
- 专利标题： APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
- 专利标题（中）： APOPTOSEINDUKTOREN ZUR BEHANDLUNG冯KREBS SOWIE VON IMMUN- UND AUTOIMMUNERKRANKUNGEN
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申请号： EP16174793.6申请日： 2010-01-15
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公开(公告)号： EP3095784A1公开(公告)日： 2016-11-23
- 发明人: KUNZER, Aaron, R. , ELMORE, Steven, W. , HEXAMER, Laura , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , WANG, Gary, T. , WANG, Xilu , WENDT, Michael, D.
- 申请人： AbbVie Inc.
- 申请人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US145611P 20090119
- 主分类号： C07D333/42
- IPC分类号： C07D333/42 ; C07D285/135 ; C07D409/12 ; A61K31/381 ; A61P35/00
摘要：
Disclosed are compounds of Formula (1), in which A 1 , Z 1 , Z 1A , Z 2 , Z 2A , L 1 and Z 3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed.
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