发明公开
EP3096775A1 SOCS MIMETICS FOR THE TREATMENT OF DISEASES
审中-公开
SOCS-MIMETIKA ZUR BEHANDLUNG VON KRANKHEITEN
- 专利标题： SOCS MIMETICS FOR THE TREATMENT OF DISEASES
- 专利标题（中）： SOCS-MIMETIKA ZUR BEHANDLUNG VON KRANKHEITEN
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申请号： EP15741027.5申请日： 2015-01-23
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公开(公告)号： EP3096775A1公开(公告)日： 2016-11-30
- 发明人: JOHNSON, Howard, M. , LARKIN, Joseph , AHMED, Chulbul, M. , JAGER, Lindsey
- 申请人： University of Florida Research Foundation, Inc.
- 申请人地址： 223 Grinter Hall Gainesville, FL 32641 US
- 专利权人： University of Florida Research Foundation, Inc.
- 当前专利权人： University of Florida Research Foundation, Inc.
- 当前专利权人地址： 223 Grinter Hall Gainesville, FL 32641 US
- 代理机构： Roberts, Michael Austin
- 优先权： US201461931363P 20140124
- 国际公布： WO2015112904 20150730
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/435 ; C12N15/63 ; C12Q1/68
摘要：
The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders. In one embodiment, one or more peptide mimetics of the invention are used to treat an autoimmune condition or disorder in a person or animal. In a specific embodiment, a mimetic of the invention is used to treat SLE in a person or animal. The subject invention also concerns methods for diagnosing and/or monitoring progression of SLE in a person or animal.
公开/授权文献
- EP3096775B1 SOCS MIMETICS FOR THE TREATMENT OF DISEASES 公开/授权日：2023-01-11
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