发明公开
- 专利标题： ACETAMINOPHEN PROTEIN ADDUCTS AND METHODS OF USE THEREOF
- 专利标题（中）： 乙酰氨基酚蛋白加合物及其使用方法
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申请号： EP15748750.5申请日： 2015-02-13
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公开(公告)号： EP3104849A1公开(公告)日： 2016-12-21
- 发明人: JAMES, Laura P. , HINSON, Jack , ROBERTS, Dean , GILL, Pritmohinder S.
- 申请人： The Board of Trustees of the University of Arkansas , Arkansas Children's Hospital Research Institute, Inc.
- 申请人地址： 2404 North University Avenue Little Rock, AR 72207 US
- 专利权人： The Board of Trustees of the University of Arkansas,Arkansas Children's Hospital Research Institute, Inc.
- 当前专利权人： The Board of Trustees of the University of Arkansas,Arkansas Children's Hospital Research Institute, Inc.
- 当前专利权人地址： 2404 North University Avenue Little Rock, AR 72207 US
- 代理机构： Spinner, David Richard
- 优先权： US201461940023P 20140214
- 国际公布： WO2015123574 20150820
- 主分类号： A61K31/167
- IPC分类号： A61K31/167
摘要：
The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.
公开/授权文献
- EP3104849B1 ACETAMINOPHEN PROTEIN ADDUCTS AND METHODS OF USE THEREOF 公开/授权日：2019-08-28
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