发明公开
EP3106468A1 CROSS-SPECIES-SPECIFIC PSMAXCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
审中-公开
BISPEZIFISCHER EINKETTIGER PSMAXCD3-ANTIKÖRPERMITARTENÜBERGREIFENDERSPEZIFITÄT
- 专利标题： CROSS-SPECIES-SPECIFIC PSMAXCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
- 专利标题（中）： BISPEZIFISCHER EINKETTIGER PSMAXCD3-ANTIKÖRPERMITARTENÜBERGREIFENDERSPEZIFITÄT
-
申请号： EP16167900.6申请日： 2009-10-01
-
公开(公告)号： EP3106468A1公开(公告)日： 2016-12-21
- 发明人: KUFER, Peter , RAUM, Tobias , KISCHEL, Roman , LUTTERBUESE, Ralf , HOFFMANN, Patrick , RAU, Doris , MANGOLD, Susanne , KLINGER, Matthias , SCHALLER, Evelyne , HAUSMANN, Susanne , FLUHR, Petra , STEIGER, Carola
- 申请人： Amgen Research (Munich) GmbH
- 申请人地址： Staffelseestrasse 2 81477 München DE
- 专利权人： Amgen Research (Munich) GmbH
- 当前专利权人： Amgen Research (Munich) GmbH
- 当前专利权人地址： Staffelseestrasse 2 81477 München DE
- 代理机构： Schiweck, Weinzierl & Koch
- 优先权： US101857P 20081001
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/22 ; C07K16/30 ; C07K16/40 ; A61K39/00
摘要：
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
信息查询
