发明公开
- 专利标题: FINE PARTICLE PRODUCTION METHOD
- 专利标题(中): FEINPARTIKELHERSTELLUNGSVERFAHREN
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申请号: EP15752000.8申请日: 2015-02-18
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公开(公告)号: EP3112017A1公开(公告)日: 2017-01-04
- 发明人: ENOMURA Masakazu
- 申请人: M Technique Co., Ltd.
- 申请人地址: 2-16, Technostage 2-chome Izumi-shi Osaka 594-1144 JP
- 专利权人: M Technique Co., Ltd.
- 当前专利权人: M Technique Co., Ltd.
- 当前专利权人地址: 2-16, Technostage 2-chome Izumi-shi Osaka 594-1144 JP
- 代理机构: Maury, Richard Philip
- 优先权: JP2014028354 20140218
- 国际公布: WO2015125819 20150827
- 主分类号: B01J19/00
- IPC分类号: B01J19/00 ; C09B48/00 ; C09B67/14 ; C09B67/20 ; A61K31/405
摘要:
This fine particle production method involves a dissolving step in which a stirrer having a rotating stirring blade is used to dissolve at least one type of fine particle raw material in a solvent to obtain a fine particle raw material solution, and a precipitation step in which the fine particle raw material solution and at least one type of precipitation solvent for precipitating the fine particle raw material from the fine particle raw material solution are introduced between at least two treatment surfaces which are arranged oppositely one another, can move closer to and farther apart from one another, and at least one of which can rotate relative to the other, and the fine particle raw material solution and the at least one type of precipitation solvent are mixed in a thin film fluid formed between the at least two treatment surfaces, and the fine particles are precipitated. The stirring energy is determined by the stirring time conditions of the stirrer, the circumferential velocity conditions of the stirring blade, and the temperature conditions of the fine particle raw material solution, and in the dissolving step, the stirring energy is varied by changing at least one of the aforementioned conditions, and by changing the stirring energy, the degree of crystallization and the crystal form of the fine particles obtained in the precipitation step are controlled.
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