发明公开
- 专利标题： HIV PROTEASE INHIBITORS
- 专利标题（中）： HIV-PROTEASEHEMMER
-
申请号： EP15759159.5申请日： 2015-03-02
-
公开(公告)号： EP3113780A1公开(公告)日： 2017-01-11
- 发明人: MCCAULEY, John, A. , BEAULIEU, Christian , BENNETT, David Jonathan , BUNGARD, Christopher, J. , CRANE, Sheldon , GRESHOCK, Thomas, J. , HOLLOWAY, M. Katharine , LESSARD, Stephanie , MCKAY, Daniel , MOLINARO, Carmela , MORADEI, Oscar Miguel , SIVALENKA, Vijayasaradhi , TRUONG, Vouy Linh , TUMMANAPALLI, Satyanarayana , WILLIAMS, Peter, D.
- 申请人： Merck Sharp & Dohme Corp. , Merck Canada Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US201461948697P 20140306
- 国际公布： WO2015134366 20150911
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377
摘要：
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
公开/授权文献
- EP3113780B1 HIV PROTEASE INHIBITORS 公开/授权日：2019-08-14
信息查询
IPC分类:
