- 专利标题: CHIMERIC ANTIGEN RECEPTOR
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申请号: EP15709320.4申请日: 2015-03-06
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公开(公告)号: EP3114147B1公开(公告)日: 2018-04-18
- 发明人: PULÉ, Martin , ANDERSON, John , THOMAS, Simon
- 申请人: UCL Business Plc.
- 申请人地址: The Network Building 97 Tottenham Court Road London W1T 4TP GB
- 专利权人: UCL Business Plc.
- 当前专利权人: UCL Business Plc.
- 当前专利权人地址: The Network Building 97 Tottenham Court Road London W1T 4TP GB
- 代理机构: D Young & Co LLP
- 优先权: GB201403972 20140306
- 国际公布: WO2015132604 20150911
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; A61K39/395 ; A61P35/00 ; C12N15/13 ; C07K16/30 ; C07K14/00 ; C07K14/705 ; C07K14/725
摘要:
Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CDR are useful in the treatment of some cancers.
公开/授权文献
- EP3114147A1 CHIMERIC ANTIGEN RECEPTOR 公开/授权日:2017-01-11
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