发明公开
EP3122373A1 MULTI-COMPONENT-MULTISTAGE MALARIA VACCINES
审中-公开
MEHRSTUFIGER MEHRKOMPONENTEN-MALARIAIMPFSTOFF
- 专利标题: MULTI-COMPONENT-MULTISTAGE MALARIA VACCINES
- 专利标题(中): MEHRSTUFIGER MEHRKOMPONENTEN-MALARIAIMPFSTOFF
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申请号: EP15713704.3申请日: 2015-03-27
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公开(公告)号: EP3122373A1公开(公告)日: 2017-02-01
- 发明人: BOES, Alexander , SPIEGEL, Holger , EDGÜ, Güven , BEISS, Veronique , SACK, Markus , REIMANN, Andreas , FISCHER, Rainer
- 申请人: FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.
- 申请人地址: Hansastraße 27c 80636 Munich DE
- 专利权人: FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.
- 当前专利权人: FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.
- 当前专利权人地址: Hansastraße 27c 80636 Munich DE
- 代理机构: Roth, Andy Stefan
- 优先权: US201461972002P 20140328; EP14001155 20140328
- 国际公布: WO2015144874 20151001
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C07K14/445
摘要:
The present disclosure relates to novel malaria vaccines composed of different recombinant proteins, in particular recombinant fusion proteins comprising several different Plasmodium falciparum antigens from the pre-erythrocytic, the blood, and the sexual parasite stages. The proteins and/or fusion proteins will be used in a mixture vaccine formulation to elicit protective immune responses in humans. Nucleic acid molecules encoding said recombinant proteins, vectors, host cells containing the nucleic acids and methods for preparation and producing such proteins; Antibodies induced or generated by the use of said malaria vaccines or said nucleic acid molecules encoding said proteins and/or fusion proteins and the use of such antibodies or recombinant derivatives for passive immunotherapy.
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