发明公开
EP3133070A1 ELIGLUSTAT (GENZ 112638) AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE FOR USE IN A METHOD OF TREATING FABRY'S OR GAUCHER'S DISEASE, THE METHOD COMPRISING ADJUSTING THE INDIVIDUAL THERAPEUTICAL DOSE TO THE P-450 METABOLISM OF THE PATIENT
审中-公开
ELIGLUSTAT（GENZ 112638）作为葡糖的FOR USE抑制剂IN法布里氏病或高雪氏的处理的方法，有顺序个人THEARAPEUTISCHEN剂量与患者P-450代谢的调节包括
- 专利标题： ELIGLUSTAT (GENZ 112638) AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE FOR USE IN A METHOD OF TREATING FABRY'S OR GAUCHER'S DISEASE, THE METHOD COMPRISING ADJUSTING THE INDIVIDUAL THERAPEUTICAL DOSE TO THE P-450 METABOLISM OF THE PATIENT
- 专利标题（中）： ELIGLUSTAT（GENZ 112638）作为葡糖的FOR USE抑制剂IN法布里氏病或高雪氏的处理的方法，有顺序个人THEARAPEUTISCHEN剂量与患者P-450代谢的调节包括
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申请号： EP16175117.7申请日： 2010-11-24
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公开(公告)号： EP3133070A1公开(公告)日： 2017-02-22
- 发明人: LIU, Hanlan , WILLIS, Chris , BHARDWAJ, Renu , COPELAND, Diane P. , HARIANAWALA, Abizer , SKELL, Jeffrey , MARSHALL, John , KOCHLING, Jianmei , PALACE, Gerard , PETERSCHMITT, Judith , SIEGEL, Craig , CHENG, Seng
- 申请人： Genzyme Corporation
- 申请人地址： 500 Kendall Street Cambridge, MA 02142 US
- 专利权人： Genzyme Corporation
- 当前专利权人： Genzyme Corporation
- 当前专利权人地址： 500 Kendall Street Cambridge, MA 02142 US
- 代理机构： Garner, Stephen
- 优先权： US264748P 20091127
- 主分类号： C07D405/06
- IPC分类号： C07D405/06 ; A61K45/06 ; A61K31/4025 ; A61P35/00
摘要：
Eliglustat (Genz 112638; N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide) as an inhibitor of the glucosylceramide synthase (GCS) for use in a method of treating Fabry's or Gaucher's disease, the method comprising adjusting the individual therapeutical dose to the P450 metabolism of the patient.
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