A sealed single-dose break-open package having: a first sheet of semi-rigid plastic material; a second sheet of flexible plastic material superimposed on and sealed to the first sheet of semi-rigid plastic material to define a sealed pocket containing a dose of a product; and a pre-weakened area, which extends transversely and is obtained in a central area of the first sheet, so as to guide, following a folding of the sealed package, a controlled breakage of the first sheet in correspondence to the pre-weakened area; the pre-weakened area has a single inner incision, which is oriented transversely and is obtained through an inner surface of the first sheet, and a single outer incision, which is oriented transversely, is obtained through an outer surface of the first sheet, and is transversely staggered relative to and longitudinally aligned with the inner incision.