发明公开
EP3150576A1 SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE
审中-公开
替代乙酰胆碱酯酸酯，维他命ZUR HERSTELLUNG UND VERWENDUNG
- 专利标题： SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE
- 专利标题（中）： 替代乙酰胆碱酯酸酯，维他命ZUR HERSTELLUNG UND VERWENDUNG
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申请号： EP15800371.5申请日： 2015-05-20
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公开(公告)号： EP3150576A1公开(公告)日： 2017-04-05
- 发明人: LI, Song , XIAO, Junhai , WANG, Lili , LONG, Long , LI, Wei , LUO, Haoming , LI, Feifei , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui , CAO, Ruiyuan
- 申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 申请人地址： No. 27 Taiping Road Haidian District Beijing 100850 CN
- 专利权人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人地址： No. 27 Taiping Road Haidian District Beijing 100850 CN
- 代理机构： Weickmann & Weickmann PartmbB
- 优先权： CN201410238255 20140530
- 国际公布： WO2015180583 20151203
- 主分类号： C07C251/86
- IPC分类号： C07C251/86 ; C07C249/16 ; C07C253/30 ; C07C255/58 ; A61K31/277 ; A61K31/165 ; A61P7/06 ; A61P7/08
摘要：
The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.
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