发明公开
EP3153498A1 N-SUBSTITUTED PHENYL GLYCINE PREPARATION METHOD
审中-公开
VERFAHREN ZUR HERSTELLUNG VON N-SUBSTITUIERTEM PHENYLGLYCIN
- 专利标题： N-SUBSTITUTED PHENYL GLYCINE PREPARATION METHOD
- 专利标题（中）： VERFAHREN ZUR HERSTELLUNG VON N-SUBSTITUIERTEM PHENYLGLYCIN
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申请号： EP15803170.8申请日： 2015-01-06
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公开(公告)号： EP3153498A1公开(公告)日： 2017-04-12
- 发明人: LIN, Zhigang , LIU, Yanqin , XU, Jun , JIANG, Yueheng , CAI, Tong
- 申请人： ABA Chemicals Corporation
- 申请人地址： 18 Dongfang Road (E) Port Development Zone, Taicang Port Taicang City, Jiangsu 215433 CN
- 专利权人： ABA Chemicals Corporation
- 当前专利权人： ABA Chemicals Corporation
- 当前专利权人地址： 18 Dongfang Road (E) Port Development Zone, Taicang Port Taicang City, Jiangsu 215433 CN
- 代理机构： ProI European Patent Attorneys
- 优先权： CN201410245765 20140605
- 国际公布： WO2015184798 20151210
- 主分类号： C07C255/58
- IPC分类号： C07C255/58 ; C07C253/30 ; C07D271/07
摘要：
Disclosed is an N-substituted phenyl glycine (dabigatran etexilate intermediate) preparation method unreported in any document, the method comprising: utilizing cheap and easily available substituted aniline (1) as raw material to condense with glyoxylic acid to form an imine, while conducting hydrogenation reduction to obtain N-(substituted phenyl) glycine. The synthetic route is not reported in any document, and the raw material is cheap and easily available; in addition, the present invention has simple unit operation and low device requirement, and is suitable for large-scale industrial production.
公开/授权文献
- EP3153498B1 N-SUBSTITUTED PHENYL GLYCINE PREPARATION METHOD 公开/授权日：2019-08-21
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