发明授权
- 专利标题： GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
- 专利标题（中）： 基于ZINC指状核苷酸的大鼠编辑
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申请号： EP16200237.2申请日： 2009-12-03
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公开(公告)号： EP3156494B1公开(公告)日： 2018-04-25
- 发明人: CUI, Xiaoxia , GEURTS, Aron M. , URNOV, Fyodor
- 申请人： Sangamo Therapeutics, Inc. , Sigma Aldrich Company
- 申请人地址： Point Richmond Tech Center 501 Canal Blvd., Suite A100 Richmond, CA 94804 US
- 专利权人： Sangamo Therapeutics, Inc.,Sigma Aldrich Company
- 当前专利权人： Sangamo Therapeutics, Inc.,Sigma Aldrich Company
- 当前专利权人地址： Point Richmond Tech Center 501 Canal Blvd., Suite A100 Richmond, CA 94804 US
- 代理机构： Weickmann & Weickmann PartmbB
- 优先权： US200985P 20081204; US205970P 20090126; US263904P 20091124
- 主分类号： C12N15/85
- IPC分类号： C12N15/85
摘要：
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
公开/授权文献
- EP3156494B8 GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES 公开/授权日：2018-09-19
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