发明公开
EP3157944A1 TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES
审中-公开
标记的HEPADNAVIRUS E抗原及其在筛选抗病毒物质中的应用
- 专利标题： TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES
- 专利标题（中）： 标记的HEPADNAVIRUS E抗原及其在筛选抗病毒物质中的应用
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申请号： EP15733379.0申请日： 2015-06-19
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公开(公告)号： EP3157944A1公开(公告)日： 2017-04-26
- 发明人: GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
- 申请人： Drexel University , Baruch S. Blumberg Institute , F. Hoffmann-La Roche AG
- 申请人地址： 3141 Chestnut Street Philadelphia, PA 19104 US
- 专利权人： Drexel University,Baruch S. Blumberg Institute,F. Hoffmann-La Roche AG
- 当前专利权人： Drexel University,Baruch S. Blumberg Institute,F. Hoffmann-La Roche AG
- 当前专利权人地址： 3141 Chestnut Street Philadelphia, PA 19104 US
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： US201462014996P 20140620
- 国际公布： WO2015193484 20151223
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; G01N33/576
摘要：
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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