An oxygen face mask and component system is provided, the mask is designed to cover a user's nose and at least partially cover a user's mouth, the mask having lateral sampling ports, an oxygen port, and a facial access opening superior to the oxygen port. The opening may be sufficiently large to allow a surgical or diagnostic procedure to be performed on part of a user's face or to allow a physician's hands or other caregiver hand's to manipulate a scope or other devices into a user's mouth. Additional components are further provided, including a colorimetric C02 detector, a sealing cap with or without a resilient sealing flap, a capnography gas analysis unit, a non-rebreather valve, a pulmonary function module, nebulizer, a gas scavenging system, a gas reservoir system, a gas filter, sample lines that are either straight or at an angle, and an aerosol mask platform; and methods of making and using a face mask are also provided.