发明公开
- 专利标题： LINKERS AND THEIR APPLICATION TOWARDS ADC
- 专利标题（中）： 链接器及其应用程序ADC
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申请号： EP15822852.8申请日： 2015-07-13
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公开(公告)号： EP3169368A1公开(公告)日： 2017-05-24
- 发明人: LI, Chun Sing , LI, Jian , CANG, Yong , CHEN, Shuhui , LI, Gang , XU, Xiongbin , LU, Lun
- 申请人： Medshine Discovery Inc.
- 申请人地址： Room 218 No.9 Gaoxin Road Gaoxin Development District Nanjing, Jiangsu 210032 CN
- 专利权人： Medshine Discovery Inc.
- 当前专利权人： Medshine Discovery Inc.
- 当前专利权人地址： Room 218 No.9 Gaoxin Road Gaoxin Development District Nanjing, Jiangsu 210032 CN
- 代理机构： dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
- 优先权： PCT/CN2014/082292 20140716
- 国际公布： WO2016008392 20160121
- 主分类号： A61K47/50
- IPC分类号： A61K47/50 ; A61K39/395 ; A61P35/00
摘要：
The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
公开/授权文献
- EP3169368B1 LINKERS AND THEIR APPLICATION TOWARDS ADC 公开/授权日：2021-02-17
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