The present invention provides methods and apparatus for safely managing the provision of radiotherapy treatment potentially in many different locations around the world. A database is formed comprising allowable ranges for each of a plurality of calibration settings in a calibration data set used to implement treatment plans in radiotherapy systems. Prior to treatment, the calibration settings of a proposed calibration data set are compared to these allowable ranges to see whether the treatment should be allowed to proceed. If one or more of the proposed calibration settings falls outside the allowable ranges, the therapy session may be stopped or prevented altogether.