发明公开
EP3174537A1 MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
审中-公开
作为胆固醇酯转运蛋白抑制剂的单环异恶唑啉
- 专利标题： MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
- 专利标题（中）： 作为胆固醇酯转运蛋白抑制剂的单环异恶唑啉
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申请号： EP15827553.7申请日： 2015-07-24
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公开(公告)号： EP3174537A1公开(公告)日： 2017-06-07
- 发明人: SHAO, Pengcheng Patrick , YE, Feng , VACHAL, Petr , THATAI, Jayanth Thiruvellore
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Böhles, Elena
- 优先权： US201462030229P 20140729
- 国际公布： WO2016018729 20160204
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61P9/00 ; C07D261/00
摘要：
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein Dl, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
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