发明公开
- 专利标题： SUBSET-OPTIMIZED CHIMERIC ANTIGEN RECEPTOR-CONTAINING T-CELLS
- 专利标题（中）： 子集优化的嵌合型含有抗原受体的T细胞
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申请号： EP15753252.4申请日： 2015-07-31
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公开(公告)号： EP3174546A1公开(公告)日： 2017-06-07
- 发明人: GUEDAN CARRIO, Sonia , JUNE, Carl H. , POSEY, Avery D. , SCHOLLER, John
- 申请人： Novartis AG , The Trustees of The University of Pennsylvania , Guedan Carrio, Sonia
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG,The Trustees of The University of Pennsylvania,Guedan Carrio, Sonia
- 当前专利权人： Novartis AG,The Trustees of The University of Pennsylvania,Guedan Carrio, Sonia
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Wilding, James Roger
- 优先权： US201462031699P 20140731
- 国际公布： WO2016019300 20160204
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K14/705
摘要：
This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4′ and CD8′ T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
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