发明公开
- 专利标题: 2-OXA-5-AZABICYCLO[2.2.1]HEPTAN-3-YL DERIVATIVES
- 专利标题(中): 2-氧杂-5-氮杂双环[2.2.1-]庚-3-基 - 衍生物
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申请号: EP15742309.6申请日: 2015-07-29
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公开(公告)号: EP3174886A1公开(公告)日: 2017-06-07
- 发明人: CECERE, Giuseppe , GALLEY, Guido , HU, Yimin , NORCROSS, Roger , PFLIEGER, Philippe , SHEN, Hong
- 申请人: F. Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: PCT/CN2014/083549 20140801
- 国际公布: WO2016016292 20160204
- 主分类号: C07D491/06
- IPC分类号: C07D491/06 ; A61K31/35 ; A61K31/407 ; A61P25/28
摘要:
The present invention relates to compounds of formula (I), wherein L is a bond, -C(O)NH-, -NHC(O)-, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH- or -NHC(O)NH-; R1 is hydrogen, lower alkyl, halogen, lower alkoxy-alkyl, lower alkoxy substituted by halogen, lower alkyl substituted by halogen or is phenyl or heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl or pyrazolyl, and wherein phenyl and heteroaryl are optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl or O-CH2-cycloalkyl; or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
公开/授权文献
- EP3174886B1 2-OXA-5-AZABICYCLO[2.2.1]HEPTAN-3-YL DERIVATIVES 公开/授权日:2021-02-17
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